CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12188
Family Name P2X purinoceptor 7 inhibitor SureCN109432 family
No. of Seeds 10 No. of Other Members 28
Family Centroid CFAMM00414300 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Orexin receptor type 2 Binder Superfamily
Class Class 96

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
IPI-145 family 2 4
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
JAK Inhibitor Momelotinib Family 33 83
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Smoothened homolog inhibitor SureCN1091571 family 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Transient receptor potential cation channel subfamily V member... 1 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 7
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Renin inhibitor AGN-PC-073MLF family 7 6
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Substance-P receptor ligand SureCN7659714 family 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN108625 family 4 1
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN109074 family 3 8
P2X purinoceptor 7 inhibitor SureCN108747 family 5 6
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
P2X purinoceptor 7 inhibitor AGN-PC-087WY0 family 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Substance-K receptor ligand SureCN9035669 family 10 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Histamine H3 receptor ligand SureCN1382602 family 6 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Substance-K receptor ligand AGN-PC-074GCM family 2 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 1 0
Reverse transcriptase/RNaseH inhibitor 152533-92-1 family 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7
Centromere-associated protein E inhibitor 5-bromo-N-[(3,4-dich... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414286 CHEMBL2218230 Bioactive SureCN109670
CFAMM00414291 CHEMBL2218240 Bioactive SureCN110594
CFAMM00414296 CHEMBL2218325 Bioactive SureCN107154
CFAMM00414289 CHEMBL2218339 Bioactive SureCN108927
CFAMM00414301 CHEMBL2218113 Bioactive SureCN108686
CFAMM00414268 CHEMBL2218136 Bioactive SureCN106039
CFAMM00414294 CHEMBL2218327 Bioactive SureCN109729
CFAMM00414287 CHEMBL2218231 Bioactive SureCN107307
CFAMM00414300 CHEMBL2218117 Bioactive SureCN109432
CFAMM00414267 CHEMBL2218139 Bioactive SureCN108431

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26236 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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