CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12191
Family Name P2X purinoceptor 7 inhibitor SureCN9931311 family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00414318 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Orexin receptor type 2 Binder Superfamily
Class Class 96

Cousin Family NamesSeedsMembers
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Smoothened homolog inhibitor SureCN1091571 family 2 2
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 5-(2-... 6 83
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... 12 1
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN108625 family 4 1
P2X purinoceptor 7 inhibitor SureCN109074 family 3 8
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Histone deacetylase 1 and Proto-oncogene tyrosine-protein kina... 4 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Substance-K receptor ligand SureCN9035669 family 10 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Substance-K receptor ligand AGN-PC-074GCM family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414319 CHEMBL2218128 Bioactive (2,3-dichlorophenyl)-[(3Z)-3-pyrrol-2-ylidene-2,5,6,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone
CFAMM00414318 CHEMBL2218127 Bioactive SureCN9931311

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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