CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12194
Family Name P2X purinoceptor 7 inhibitor SureCN3652462 family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00414327 Functional Category Bioactive
Superfamily P2X purinoceptor 7 Binder Superfamily 4
Class Class 1375

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Coagulation factor X inhibitor AGN-PC-00QIZ9 family 2 15
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Substance-P receptor ligand AGN-PC-075NUD family 4 1
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor SureCN3659568 family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
P2X purinoceptor 7 inhibitor SureCN3652181 family 1 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Progesterone receptor ligand SureCN3031001 family 8 40
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414328 CHEMBL2218631 Bioactive SureCN3659549
CFAMM00414327 CHEMBL2218539 Bioactive SureCN3652462
CFAMM00414333 CHEMBL2218166 Bioactive SureCN3658186
CFAMM00414331 CHEMBL2218749 Bioactive AGN-PC-050YNA
CFAMM00414330 CHEMBL2218580 Bioactive SureCN3654170

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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