CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12202
Family Name P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-oxoimidazolidine-4-carboxamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00414371 Functional Category Bioactive
Superfamily Glutathione S-transferase Inhibitor Praziquantel Superfamily
Class Class 107

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-P receptor Ligand Vestipitant Family 14 137
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 6
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 9 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
P2X purinoceptor 7 inhibitor SureCN2574353 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414374 CHEMBL2218390 Bioactive (4S)-1,3-dimethyl-N-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-oxoimidazolidine-4-carboxamide
CFAMM00414372 CHEMBL2218494 Bioactive (4S)-N-[[2-fluoro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-2-oxoimidazolidine-4-carboxamide
CFAMM00414371 CHEMBL2218363 Bioactive (4S)-3-methyl-N-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-2-oxoimidazolidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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