CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12203
Family Name P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxo-1-pyrimidin-2-ylimidazolidine-4-carboxamide family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00414382 Functional Category Bioactive
Superfamily Prostaglandin D2 receptor and Lysosomal Pro-X carboxypeptidase Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Prothrombin inhibitor SureCN7371121 family 13 3
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
Histone deacetylase 1 and Histone deacetylase 3 inhibitor 2-[(... 1 5
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Lysosomal Pro-X carboxypeptidase inhibitor methyl N-[4-[[6-[[(... 1 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 1 0
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 1 2
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase receptor TYRO3 and Tyrosine-protein ki... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414380 CHEMBL2218547 Bioactive (4S)-N-[(3-chloro-2-methylphenyl)methyl]-3-methyl-2-oxo-1-pyrimidin-2-ylimidazolidine-4-carboxamide
CFAMM00414377 CHEMBL2218384 Bioactive (4S)-1-(5-chloropyrimidin-2-yl)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00414383 CHEMBL2218371 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1-(5-fluoropyrimidin-2-yl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00414382 CHEMBL2218542 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-3-methyl-2-oxo-1-pyrimidin-2-ylimidazolidine-4-carboxamide
CFAMM00414375 CHEMBL2218452 Bioactive SureCN1637498
CFAMM00414381 CHEMBL2218544 Bioactive (4S)-N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-2-oxo-1-pyrimidin-2-ylimidazolidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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