CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12204
Family Name P2X purinoceptor 7 inhibitor SureCN1635928 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00414392 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Beta-lactamase Binder Superfamily 2
Class Class 2253

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Reverse transcriptase Inhibitor PT-109 Family 6 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Prothrombin inhibitor SureCN7371121 family 13 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 5 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 1 0
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 1 2
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 7 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Integrin alpha-V and Integrin beta-6 inhibitor SureCN12259087 ... 3 4
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414392 CHEMBL2218463 Bioactive SureCN1635928
CFAMM00414391 CHEMBL2218524 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-2-oxo-1-pyridin-2-ylimidazolidine-4-carboxamide
CFAMM00414389 CHEMBL2218558 Bioactive (4S)-N-[(2,4-dichlorophenyl)methyl]-1-(3-fluoropyridin-2-yl)-3-methyl-2-oxoimidazolidine-4-carboxamide
CFAMM00414388 CHEMBL2218552 Bioactive (4S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-3-methyl-1-(3-methylpyridin-2-yl)-2-oxoimidazolidine-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26844 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543