CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12211
Family Name P2X purinoceptor 7 inhibitor SureCN3721807 family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00414434 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Alpha-1D adrenergic receptor Binder Superfamily
Class Class 3044

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Benzodiazepine receptor ligand benzodiazepine derivative Oxaze... 4 0
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor AGN-PC-00QIZ9 family 2 15
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Mitogen-activated protein kinase 14 inhibitor AGN-PC-044QVW fa... 10 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3659568 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
Translocator protein inhibitor CHEMBL2332254 family 6 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Progesterone receptor ligand CHEMBL403139 family 2 0
Melanocortin receptor 4 ligand 2-amino-N-[(2R)-3-(2,4-dichloro... 5 5
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
Progesterone receptor ligand SureCN3031001 family 8 40
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414435 CHEMBL2218704 Bioactive AGN-PC-088GYB
CFAMM00414434 CHEMBL2218648 Bioactive SureCN3721807
CFAMM00414433 CHEMBL2218731 Bioactive AGN-PC-088GBT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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