CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12217
Family Name Vascular endothelial growth factor receptor 2 ligand N-(1,3-Thiazol-2-yl)pyridin-2-amine 12 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00414453 Functional Category Bioactive
Superfamily Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine Superfamily
Class Class 2616

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
DNA primase Inhibitor Bay 57-1293 Family 1 2
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19
Reverse transcriptase Inhibitor PT-109 Family 6 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 2
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand N-[5-[(4-thiophen-3-yl-1... 1 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-02WPKX family 2 5
Cholinesterase and Acetylcholinesterase inhibitor 3-[ethyl-[3-... 6 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Metabotropic glutamate receptor 5 ligand 2-methyl-N-(6-methylp... 1 8
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand AC1NS6KZ ... 1 0
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HLHQ family 2 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Neuropeptide Y receptor type 5 ligand SureCN6213316 family 3 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4
Probable G-protein coupled receptor 142 ligand (2S)-3-phenyl-N... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414453 CHEMBL221875 Bioactive N-(1,3-Thiazol-2-yl)pyridin-2-amine 12
CFAMM00414452 CHEMBL98475 Bioactive N-(1,3-Thiazol-2-yl)pyridin-2-amine 2
CFAMM00414451 CHEMBL224035 Bioactive AC1NS6KB
CFAMM00414450 CHEMBL221926 Bioactive N-(1,3-Thiazol-2-yl)pyridin-2-amine 13

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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