CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12218
Family Name Coagulation factor X and Prothrombin inhibitor SureCN5819494 family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00377302 Functional Category Bioactive
Superfamily Coagulation factor X and Prothrombin Binder Superfamily 12
Class Class 1276

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
Kinase and DNAPKi Inhibitor CC-115 Family 1 1
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Coagulation factor X Inhibitor SN429 Family 23 100
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Poly [ADP-ribose] polymerase 1 Inhibitor 2-phenylpyrazolo-[1,5... 1 1
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Apoptosis regulator Bcl-2 and Bcl-2-like protein 1 inhibitor 1... 1 18
Coagulation factor X inhibitor SureCN8169809 family 12 18
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Coagulation factor X inhibitor SureCN8168539 family 3 0
Coagulation factor X inhibitor SureCN8165148 family 4 0
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Coagulation factor X inhibitor DPC 423 derivative, 8 family 1 2
Mitogen-activated protein kinase 8 inhibitor 5-[(6-chloro-1-ox... 5 7
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Progesterone receptor ligand AGN-PC-00OK6G family 7 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Coagulation factor X inhibitor AGN-PC-046QCP family 2 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Coagulation factor X inhibitor SureCN5254091 family 5 0
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Apoptosis regulator Bcl-2 and Bcl2-associated agonist of cell ... 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414466 CHEMBL221968 Bioactive AGN-PC-046QCT
CFAMM00414459 CHEMBL374305 Bioactive SureCN6786319
CFAMM00414458 CHEMBL376227 Bioactive AGN-PC-046QCX
CFAMM00414455 CHEMBL385756 Bioactive AGN-PC-046QCQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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