CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12219
Family Name B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(1-methyltetrazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00414469 Functional Category Bioactive
Superfamily B1 bradykinin receptor and Cannabinoid receptor 2 Binder Superfamily
Class Class 3234

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 1 0
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
B1 bradykinin receptor ligand 3-[(1R)-1-[5-[5-chloro-3-fluoro-... 7 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 3-[3-... 4 9
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Transient receptor potential cation channel subfamily V member... 3 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 3-[3-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(9-... 7 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414467 CHEMBL374779 Bioactive N-[4-chloro-2-[[(1R)-1-[4-(2-cyano-3-fluorophenyl)phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
CFAMM00414472 CHEMBL387638 Bioactive N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(2-methyltetrazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
CFAMM00414470 CHEMBL225006 Bioactive N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(trifluoromethyl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
CFAMM00414476 CHEMBL225218 Bioactive N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide
CFAMM00414469 CHEMBL221984 Bioactive N-[4-chloro-2-[[(1R)-1-[4-[3-fluoro-2-(1-methyltetrazol-5-yl)phenyl]phenyl]ethyl]amino]pyridin-3-yl]-2-cyanoacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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