CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12226
Family Name Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoic acid family
No. of Seeds 5 No. of Other Members 22
Family Centroid CFAMM00414508 Functional Category Bioactive with Natural Product
Superfamily Beta-1 adrenergic receptor and Beta-3 adrenergic receptor Binder Superfamily 2
Class Class 4220

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 3 13
Beta-1 adrenergic receptor ligand 4-[2-[[(2S)-3-(2-cyano-5-flu... 3 2
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 4 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Transient receptor potential cation channel subfamily V member... 1 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor dimethyl 5-[4-[(4-m... 1 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 12 13
Integrin alpha-4 inhibitor SureCN14558473 family 7 4
Integrin alpha-4 inhibitor SureCN14558471 family 16 2
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Diacylglycerol O-acyltransferase 1 inhibitor (1R,2R)-2-[4-[3-f... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7496449 f... 3 2
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Capsid scaffolding protein inhibitor AC1MHP20 family 3 3
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
Neuropeptide Y receptor type 1 ligand 1-(1-benzofuran-6-yl)-3-... 1 1
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 0
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 1
RAF proto-oncogene serine/threonine-protein kinase inhibitor 3... 1 0
Glucagon receptor ligand 2-chloro-N-[[3-chloro-4-(4-chlorophen... 1 7
methoxybenzoate NP (2-hydroxy-6-methoxyquinolin-3-yl)methyl 4-... 2 1
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414499 CHEMBL438983 Bioactive methyl 4-[[4-(4-fluorophenoxy)cyclohexyl]carbamoylamino]benzoate
CFAMM00414526 CHEMBL222161 Bioactive methyl 3-[[4-(4-fluorophenoxy)cyclohexyl]carbamoylamino]benzoate
CFAMM00414498 CHEMBL2397148 Bioactive Urea-based compound, 22
CFAMM00414504 CHEMBL2397138 Bioactive N-methyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzamide
CFAMM00414508 CHEMBL243793 Bioactive 3-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxybenzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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