CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12230
Family Name Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3 ligand 4,4-bis(4-fluorophenyl)-1-[(3R)-1-[2-(3-fluorophenyl)-2-oxoethyl]-1-methylpyrrolidin-1-ium-3-yl]imidazolidin-2-one family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00280215 Functional Category Bioactive
Superfamily Muscarinic receptor 3 and Muscarinic acetylcholine receptor M3 Binder Superfamily
Class Class 1354

Cousin Family NamesSeedsMembers
Sodium channel Ligand hydantoin derivative Phenytoin Family 2 25
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-P receptor Ligand Vestipitant Family 14 137
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Cathepsin K and Cysteine proteinase B inhibitor N-[(2S)-1-[(3a... 1 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0
Cannabinoid receptor 1 and Fatty-acid amide hydrolase 1 ligand... 2 3
Prolyl endopeptidase inhibitor 3eq9 family 1 0
Cannabinoid receptor 1 ligand 3-butyl-5,5-bis(4-iodophenyl)-2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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