CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12232
Family Name Endothelin-1 receptor and Endothelin B receptor ligand AGN-PC-03PC0A family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00017080 Functional Category Bioactive
Superfamily Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-032ZUC f... 2 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Cysteinyl leukotriene receptor 1 ligand 1-[[4-[(2-chlorophenyl... 4 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00414543 CHEMBL278349 Bioactive AGN-PC-076HND
CFAMM00414549 CHEMBL22249 Bioactive AGN-PC-076HOQ
CFAMM00414548 CHEMBL22513 Bioactive 3-[1-(1,3-benzodioxol-5-yl)-2-[(2-ethoxy-4-methylphenyl)sulfonylamino]-2-oxoethyl]-1-methylindole-6-carboxamide
CFAMM00414550 CHEMBL433619 Bioactive AGN-PC-076HVA

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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