CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12234
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic receptor ligand AGN-PC-003IZ5 family
No. of Seeds 6 No. of Other Members 11
Family Centroid CFAMM00179203 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(3) dopamine receptor Binder Superfamily 2
Class Class 1458

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Tubulin Inhibitor WR85915 Family 3 15
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 6
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Transient receptor potential cation channel subfamily V member... 1 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
C-C chemokine receptor type 1 ligand SureCN3164653 family 2 1
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Melanocortin receptor 4 ligand 3-amino-N-[(2R)-3-(2,4-dichloro... 1 9
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor 2-(5-chloro-2-oxo-1,3-benzoxazo... 1 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R... 8 9
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Urotensin-2 receptor and Kappa-type opioid receptor ligand 6,7... 2 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6627432 f... 6 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Acyl-CoA desaturase and Acyl-CoA desaturase 1 inhibitor SureCN... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 0
P2X purinoceptor 7 inhibitor SureCN3722920 family 4 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
Neuropeptide Y receptor type 5 ligand SureCN3380276 family 1 1
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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