CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12247
Family Name Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A ligand AKI-001 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00414623 Functional Category Bioactive
Superfamily Aurora kinase A and Aurora kinase B Binder Superfamily 6
Class Class 3568

Cousin Family NamesSeedsMembers
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor 3-(Indol-2-yl)i... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414626 CHEMBL469205 Bioactive pentacyclic compound, 33
CFAMM00414623 CHEMBL223147 Bioactive AKI-001

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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