CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12249
Family Name Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]-3-(1H-indol-3-yloxy)propanamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00414634 Functional Category Bioactive
Superfamily Acetylcholinesterase and Cholinesterase Binder Superfamily
Class Class 3193

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414629 CHEMBL372202 Bioactive AGN-PC-00BNTL
CFAMM00414634 CHEMBL223277 Bioactive N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]-3-(1H-indol-3-yloxy)propanamide
CFAMM00414633 CHEMBL225077 Bioactive N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]-3-(1H-indol-3-yloxy)propanamide
CFAMM00414631 CHEMBL225327 Bioactive N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1H-indol-3-yloxy)propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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