CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12250
Family Name Renin inhibitor N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-4,4-difluoro-3-hydroxy-5-oxopentan-2-yl]-6-(methylcarbamothioylamino)-2-[[2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00414636 Functional Category Bioactive
Superfamily Renin and Cathepsin D Binder Superfamily 2
Class Class 1444

Cousin Family NamesSeedsMembers
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Renin Inhibitor CP-80794 Family 16 112
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Renin inhibitor AGN-PC-076HPD family 1 0
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
Renin and Cathepsin E inhibitor (2S)-N-[(2S,3S,5R)-1-cyclohexy... 1 0
Renin inhibitor (3S)-3-hydroxy-6-methyl-N-(2-methylbutyl)-4-[[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414636 CHEMBL22330 Bioactive N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-4,4-difluoro-3-hydroxy-5-oxopentan-2-yl]-6-(methylcarbamothioylamino)-2-[[2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamide
CFAMM00414640 CHEMBL23199 Bioactive N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]-6-(methylcarbamothioylamino)-2-[[2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamide
CFAMM00414639 CHEMBL287265 Bioactive (2S)-N-[(2S)-1-cyclohexyl-4,4-difluoro-3-hydroxy-5-(2-morpholin-4-ylethylamino)-5-oxopentan-2-yl]-6-(methylcarbamothioylamino)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hexanamide
CFAMM00414638 CHEMBL281153 Bioactive N-[(3S)-5-[2-(2-aminoethyl)morpholin-4-yl]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]-6-(methylcarbamothioylamino)-2-[[2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]hex-4-ynamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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