CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12254
Family Name 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2B ligand SureCN13119155 family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00054526 Functional Category Bioactive
Superfamily D(3) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Sulpiride Family 7 38
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 2 4
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-074R8E family 2 1
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45569 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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