CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12284
Family Name Sodium-dependent noradrenaline transporter and Sodium-dependent serotonin transporter inhibitor (1S,2R)-2-(aminomethyl)-1-(1,3-benzodioxol-5-yl)-N,N-bis(prop-2-enyl)cyclopropane-1-carboxamide family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00155374 Functional Category Bioactive
Superfamily Substance-P receptor Binder Superfamily
Class Class 333

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Zucapsacin family 7 177
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand DA-5018 Family 14 73
Ivabradine family 1 11
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Transient receptor potential cation channel subfamily V member... 3 18
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Putative NP ZINC04041531 Family 40 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414844 CHEMBL225210 Bioactive (4r,5r)-5-Amino-1-[2-(1,3-Benzodioxol-5-Yl)ethyl]-4-(2,4,5-Trifluorophenyl)piperidin-2-One
CFAMM00414836 CHEMBL538090 Bioactive (4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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