CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12287
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 7 ligand 1-(3,4-dihydro-1H-isoquinolin-2-yl)-6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]hexan-1-one family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00414851 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and Cholinesterase Binder Superfamily
Class Class 2519

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Cholinesterase Inhibitor 1-(10h-phenothiazin-10-yl)-2-phenylbu... 10 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 2A Ligand Cinanserin Family 3 27
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
Sigma non-opioid intracellular receptor 1 and Histamine H1 rec... 5 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 18 12
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Sigma non-opioid intracellular receptor 1 ligand 3-[4-(azepan-... 8 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-0760MQ f... 1 2
Substance-P receptor ligand AGN-PC-073MZ3 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00414851 CHEMBL493305 Bioactive 1-(3,4-dihydro-1H-isoquinolin-2-yl)-6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]hexan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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