CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1230
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-methoxyphenyl)-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-2-one family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00320881 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 11
Class Class 3316

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Substance-K receptor Ligand MEN-14933 Family 13 154
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 18
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Translocator protein inhibitor CHEMBL2332259 family 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN6152927 family 7 3
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
C-X-C chemokine receptor type 3 ligand 1-[1-[[(1S,5R)-6,6-dime... 2 3
Cholinesterase inhibitor (13-methyl-5,6,8,13a-tetrahydroisoqui... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00320882 CHEMBL549894 Bioactive 1-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]-3-[3-(trifluoromethoxy)phenyl]imidazolidin-2-one
CFAMM00320881 CHEMBL559920 Bioactive 1-(3-methoxyphenyl)-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-2-one
CFAMM00320878 CHEMBL114101 Bioactive SureCN7275945
CFAMM00320877 CHEMBL559919 Bioactive 1-[3-(trifluoromethoxy)phenyl]-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26858 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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