CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12304
Family Name Dual specificity protein kinase CLK4 and Mitogen-activated protein kinase kinase kinase kinase 4 inhibitor 2-(2-chloropyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00288290 Functional Category Bioactive
Superfamily Chymase and Stromelysin-3 Binder Superfamily
Class Class 1033

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Inhibitor of nuclear factor kappa-B kinase subunit epsilon and... 1 4
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A Inhibitor 6-chloro-n-(2-mo... 5 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Glucagon receptor ligand 3-[[4-[(1R,2S)-1-(4-chlorophenyl)-1-(... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0
C-X-C chemokine receptor type 2 ligand 6-chloro-N-(4-fluorophe... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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