CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12370
Family Name Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00415274 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Coagulation factor X and Prothrombin Inhibitor BMS-344577 Family 13 12
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lyn and Tyrosine-protein kinase Lck in... 1 6
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Gonadotropin-releasing hormone receptor ligand AGN-PC-034WF4 f... 8 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Glucose-dependent insulinotropic receptor and Potassium voltag... 4 0
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Angiopoietin-1 receptor ligand SureCN1939461 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Transient receptor potential cation channel subfamily V member... 2 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-03J2ZU f... 1 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-0766EI f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415274 CHEMBL228926 Bioactive SureCN4461871
CFAMM00415272 CHEMBL228976 Bioactive SureCN4462275

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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