CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12375
Family Name C-C chemokine receptor type 2 ligand N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(methylcarbamoylamino)-1,3-thiazol-4-yl]-4-(4-phenylpiperidin-1-yl)butanamide family
No. of Seeds 22 No. of Other Members 16
Family Centroid CFAMM00415310 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 and Transient receptor potential cation channel subfamily M member 8 Binder Superfamily
Class Class 1257

Cousin Family NamesSeedsMembers
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor 7-me... 3 14
Adenosine receptor A1 Ligand N-(4-phenyl-thiazol-2-yl)-benzami... 5 2
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Gonadotropin-releasing hormone receptor ligand ethyl N-[4-[4-[... 2 17
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 2
C-C chemokine receptor type 2 ligand AGN-PC-0765RZ family 1 0
Long-chain fatty acid transport protein 1 inhibitor N-(4,5-dim... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415325 CHEMBL388487 Bioactive 2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
CFAMM00415305 CHEMBL437552 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(dimethylcarbamoylamino)-1,3-thiazol-4-yl]-4-(4-phenylpiperidin-1-yl)butanamide
CFAMM00415297 CHEMBL397997 Bioactive methyl N-[4-[(2S)-1-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-oxo-4-(4-phenylpiperidin-1-yl)butan-2-yl]-1,3-thiazol-2-yl]carbamate
CFAMM00415330 CHEMBL388868 Bioactive (2R)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(methylcarbamoylamino)-1,3-thiazol-4-yl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
CFAMM00415323 CHEMBL395721 Bioactive AGN-PC-0765SL
CFAMM00415296 CHEMBL397996 Bioactive (2S)-2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(4-phenylpiperidin-1-yl)butanamide
CFAMM00415310 CHEMBL230166 Bioactive N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(methylcarbamoylamino)-1,3-thiazol-4-yl]-4-(4-phenylpiperidin-1-yl)butanamide
CFAMM00415316 CHEMBL397749 Bioactive AGN-PC-0765SS
CFAMM00415329 CHEMBL388867 Bioactive (2R)-2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
CFAMM00415322 CHEMBL438304 Bioactive 2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-[(3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
CFAMM00415302 CHEMBL230727 Bioactive AGN-PC-0765RQ
CFAMM00415315 CHEMBL389771 Bioactive (2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(methylcarbamoylamino)-1,3-thiazol-4-yl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
CFAMM00415308 CHEMBL229316 Bioactive 2-(2-amino-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-[(3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]butanamide
CFAMM00415334 CHEMBL389888 Bioactive 2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-(4-phenylpiperidin-1-yl)butanamide
CFAMM00415314 CHEMBL230794 Bioactive AGN-PC-0765SK
CFAMM00415327 CHEMBL397948 Bioactive (2S)-2-(2-acetamido-1,3-thiazol-4-yl)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-4-spiro[indene-1,4'-piperidine]-1'-ylbutanamide
CFAMM00415320 CHEMBL230281 Bioactive (2S)-N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-2-[2-(methylcarbamoylamino)-1,3-thiazol-4-yl]-4-(4-phenylpiperidin-1-yl)butanamide
CFAMM00415333 CHEMBL396517 Bioactive AGN-PC-0765RS
CFAMM00415300 CHEMBL230684 Bioactive AGN-PC-0765SJ
CFAMM00415313 CHEMBL230790 Bioactive AGN-PC-0765RX
CFAMM00415326 CHEMBL397747 Bioactive AGN-PC-0765SI
CFAMM00415332 CHEMBL387583 Bioactive AGN-PC-0765SQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27527 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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