CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12377
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureCN1037543 family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00148721 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
SB989 family 17 91
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Prothrombin inhibitor SureCN5854779 family 4 9
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 2 1
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Cannabinoid receptor 1 ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 1 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Transient receptor potential cation channel subfamily V member... 4 0
Substance-P receptor ligand SureCN7659714 family 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 5 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Cannabinoid receptor 1 ligand N-(3,3a,4,5,6,6a-hexahydro-1H-cy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Histamine H3 receptor ligand SureCN1382602 family 6 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2
Centromere-associated protein E inhibitor 5-bromo-N-[(3,4-dich... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415348 CHEMBL389175 Bioactive AGN-PC-042GVW
CFAMM00415346 CHEMBL229698 Bioactive AGN-PC-0765QU
CFAMM00415351 CHEMBL229749 Bioactive AGN-PC-0765QW
CFAMM00415350 CHEMBL229584 Bioactive AGN-PC-03I5UD
CFAMM00415343 CHEMBL390543 Bioactive AGN-PC-0765QS

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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