CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12382
Family Name Mitogen-activated protein kinase kinase kinase 8 inhibitor SureCN4962017 family
No. of Seeds 11 No. of Other Members 2
Family Centroid CFAMM00415390 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase kinase kinase 8 and Stromelysin-1 Inhibitor 8-chloro-quinoline-3-carbonitrile Superfamily
Class Class 2492

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 2 2
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN413... 1 1
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 1 0


External ID

Functional Category

Molecule Name

CFAMM00415400 CHEMBL498222 Bioactive AGN-PC-071J8D
CFAMM00415393 CHEMBL230117 Bioactive Cyanoquinoline, 35
CFAMM00415392 CHEMBL495617 Bioactive SureCN4959910
CFAMM00415398 CHEMBL498070 Bioactive AGN-PC-071J8J
CFAMM00415391 CHEMBL498029 Bioactive AGN-PC-071J8V
CFAMM00415397 CHEMBL498071 Bioactive AGN-PC-071J8K
CFAMM00415390 CHEMBL498028 Bioactive SureCN4962017
CFAMM00415396 CHEMBL501709 Bioactive SureCN4959879
CFAMM00415389 CHEMBL496595 Bioactive SureCN6071565
CFAMM00415395 CHEMBL523059 Bioactive AGN-PC-071J8Y
CFAMM00415394 CHEMBL527026 Bioactive 915363-56-3

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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