CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM124
Family Name Prothrombin inhibitor SureCN7371121 family
No. of Seeds 13 No. of Other Members 3
Family Centroid CFAMM00307533 Functional Category Bioactive
Superfamily Prothrombin and Trypsin-1 Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Transient receptor potential cation channel subfamily V member... 6 66
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Transient receptor potential cation channel subfamily V member... 2 26
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 5 0
Prothrombin inhibitor SureCN5856722 family 3 16
Corticotropin-releasing factor receptor 1 ligand 5-chloro-1-[(... 1 2
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Prothrombin inhibitor SureCN7111496 family 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
Beta-secretase 2 and Beta-secretase 1 inhibitor N-[3-[(1S,7S)-... 7 4
Beta-secretase 1 and Beta-secretase 2 inhibitor N-[3-[(4S)-2-a... 6 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Transient receptor potential cation channel subfamily V member... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0
NADPH oxidase 4 and NADPH oxidase 1 inhibitor 2-(2-chloropheny... 2 5
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
Putative NP ZINC40309120 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307532 CHEMBL281982 Bioactive AGN-PC-073GVK
CFAMM00307525 CHEMBL356296 Bioactive AGN-PC-00GO8E
CFAMM00307531 CHEMBL1682693 Bioactive AGN-PC-09QMWR
CFAMM00307524 CHEMBL28474 Bioactive AGN-PC-073GVL
CFAMM00307530 CHEMBL1682694 Bioactive AGN-PC-08Y2XU
CFAMM00307536 CHEMBL1682763 Bioactive SureCN7369397
CFAMM00307529 CHEMBL26804 Bioactive AGN-PC-073GWS
CFAMM00307535 CHEMBL1682762 Bioactive SureCN7370934
CFAMM00307528 CHEMBL102174 Bioactive AGN-PC-006NV9
CFAMM00307534 CHEMBL26679 Bioactive AGN-PC-073GVE
CFAMM00307527 CHEMBL416754 Bioactive AGN-PC-073GZ9
CFAMM00307533 CHEMBL25845 Bioactive SureCN7371121

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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