CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12411
Family Name Vascular endothelial growth factor receptor 2 ligand 2-aminobenzimidazole, 9 family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00415604 Functional Category Bioactive
Superfamily RAF proto-oncogene serine/threonine-protein kinase and Glucagon receptor Binder Superfamily
Class Class 681

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Serine/threonine-protein kinase PLK1 Inhibitor GSK461364 Family 40 84
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 8 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Elongation factor 1-alpha 1 and Elongation factor 1-alpha 2 in... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 5 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Glucokinase inhibitor SureCN1657199 family 10 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415602 CHEMBL231067 Bioactive 2-aminobenzimidazole, 10
CFAMM00415604 CHEMBL231269 Bioactive 2-aminobenzimidazole, 9
CFAMM00415603 CHEMBL231168 Bioactive 2-aminobenzimidazole, 8

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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