CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12424
Family Name Transient receptor potential cation channel subfamily V member 1 and Transient receptor potential cation channel subfamily A member 1 ligand N-(4-tert-butylphenyl)-6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00415658 Functional Category Bioactive with Natural Product
Superfamily Kinesin-like protein KIF11 and Transient receptor potential cation channel subfamily V member 1 Binder Superfamily
Class Class 770

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 6 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415658 CHEMBL2312050 Bioactive N-(4-tert-butylphenyl)-6-hydroxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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