CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12426
Family Name Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phenylphenoxy)-1H-benzimidazole family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00415670 Functional Category Bioactive
Superfamily Neuropeptide Y receptor type 5 and Acyl-CoA desaturase Binder Superfamily
Class Class 937

Cousin Family NamesSeedsMembers
Potassium-transporting ATPase alpha chain 1 Inhibitor Rabepraz... 4 113
Histamine H1 receptor Ligand Astemizole Family 7 240
Potassium-transporting ATPase alpha chain 1 Inhibitor Pantopra... 1 3
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 2 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Neuropeptide Y receptor type 5 ligand 2-phenyl-4-(6-propylsulf... 12 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 2-(2,2-difluoro-2-phenyl... 2 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Arachidonate 15-lipoxygenase inhibitor SureCN14288120 family 3 12
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Sterol O-acyltransferase 1 inhibitor 1,1-bis[5-[[4,5-bis(4-met... 1 15
Glucagon receptor ligand SureCN2647807 family 3 7
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415671 CHEMBL2312072 Bioactive 6-ethylsulfonyl-2-(3-phenylphenoxy)-1H-benzimidazole
CFAMM00415670 CHEMBL2312073 Bioactive 6-ethylsulfonyl-2-(4-phenylphenoxy)-1H-benzimidazole
CFAMM00415669 CHEMBL2312074 Bioactive 6-ethylsulfonyl-2-(4-pyridin-2-ylphenoxy)-1H-benzimidazole
CFAMM00415668 CHEMBL2312075 Bioactive 6-ethylsulfonyl-2-(6-phenylpyridin-3-yl)oxy-1H-benzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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