CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12428
Family Name TRAF2 and NCK-interacting protein kinase and Serine/threonine-protein kinase PAK 1 inhibitor 2-[3-[5-chloro-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]phenyl]acetonitrile family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00167469 Functional Category Bioactive
Superfamily Peptide deformylase, mitochondrial Inhibitor Epiroprim Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
AP26113 family 16 90
SB1518 family 7 103
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
ALK tyrosine kinase receptor and Insulin receptor ligand SureC... 7 1
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Transient receptor potential cation channel subfamily V member... 2 4
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Proto-oncogene tyrosine-protein kinase Src inhibitor Anilinoim... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415680 CHEMBL2312145 Bioactive 4-(5-chloro-2-methoxyphenyl)-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]pyridin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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