CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12431
Family Name G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor Cdk2/9 Inhibitor family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00126970 Functional Category Bioactive
Superfamily Aurora kinase B and Aurora kinase A Inhibitor CYC116 Superfamily
Class Class 817

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 2-(4-hydroxy... 2 15
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0


External ID

Functional Category

Molecule Name

CFAMM00415700 CHEMBL601064 Bioactive 2-methyl-N-(3-nitrophenyl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazolin-8-amine
CFAMM00415697 CHEMBL598992 Bioactive 8-N-(3-nitrophenyl)-4,5-dihydro-[1,3]thiazolo[4,5-h]quinazoline-2,8-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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