CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12439
Family Name Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated protein kinase kinase kinase kinase 4 ligand 2-(3,5-dichloroanilino)-4-[[4-(dimethylamino)cyclohexyl]amino]-N-(1-methylpiperidin-4-yl)pyrimidine-5-carboxamide family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00169919 Functional Category Bioactive
Superfamily Tyrosine-protein kinase receptor TYRO3 and P-selectin Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and P-selectin ligand 2... 2 3
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Neuropeptide Y-Y2 receptor and Neuropeptide Y receptor type 2 ... 1 1
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Tyrosine-protein kinase receptor TYRO3 and Tyrosine-protein ki... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415770 CHEMBL2312650 Bioactive 2-(3,5-dichloroanilino)-N-(1-methylpiperidin-4-yl)-4-(oxan-4-ylamino)pyrimidine-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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