CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12450
Family Name cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A inhibitor 1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]piperidin-4-ol family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00333036 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 Inhibitor LY2784544 Superfamily
Class Class 37

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
HCV NS4B protein Inhibitor Clemizole Family 2 43
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 5
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Adenosine receptor A2a and Adenosine receptor A2b ligand 6-(2,... 6 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00415834 CHEMBL2313239 Bioactive 1-[[1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]methyl]pyrrolidin-3-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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