CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12481
Family Name Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(methylsulfinylmethyl)naphthalene-1-carbonyl]amino]pyridine-2-carboxamide family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00416070 Functional Category Bioactive
Superfamily Macrophage metalloelastase Inhibitor PF-00356231 Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
26S proteasome Inhibitor Bortezomib Family 7 65
Prothrombin Inhibitor Ximelegatran Family 8 157
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416070 CHEMBL2316109 Bioactive N-(cyclobutylmethyl)-3-[[4-(methylsulfinylmethyl)naphthalene-1-carbonyl]amino]pyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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