CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12498
Family Name Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family
No. of Seeds 9 No. of Other Members 4
Family Centroid CFAMM00235090 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily
Class Class 168

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Renin Inhibitor CP-80794 Family 16 112
Cruzipain Inhibitor WRR-204 Family 18 35
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Pol polyprotein inhibitor 169168-45-0 family 7 11
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Cathepsin D and Beta-secretase 1 inhibitor tert-butyl N-[(2S)-... 1 0
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor SureCN8293614 family 2 0
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Pol polyprotein inhibitor 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfin... 15 15
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-d... 1 10
Cytochrome P450 3A4 and Beta-secretase 1 inhibitor N-[(2S,3R)-... 2 40
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Pol polyprotein inhibitor Sulfone deriv. 31 family 15 4
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3
Beta-secretase 1 and Cathepsin D inhibitor N-[4-[[(3S,4S,5R)-5... 1 12
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Renin inhibitor (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl... 5 0
Pol polyprotein inhibitor AC1LAH8S family 11 1
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Pol polyprotein inhibitor AC1LACBC family 2 0
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(3R)... 1 0
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-4-[[1-[3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416145 CHEMBL398775 Bioactive SureCN14347876
CFAMM00416142 CHEMBL231669 Bioactive SureCN14347867
CFAMM00416141 CHEMBL232490 Bioactive SureCN14347864
CFAMM00416146 CHEMBL409948 Bioactive S-(oxolan-3-yl) N-[(2S)-3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamothioate
CFAMM00416139 CHEMBL231864 Bioactive 2-cyanoethyl N-[3-butylsulfonyl-1-[[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylphenyl)methylamino]-3-hydroxybutan-2-yl]amino]-1-oxopropan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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