CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12499
Family Name Mast/stem cell growth factor receptor Kit and Epithelial discoidin domain-containing receptor 1 ligand N-(3-methoxyphenyl)-4-methyl-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00416147 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand GW876008 Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
DCC-2036 family 2 5
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
MK-6096 family 3 69
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Smoothened homolog inhibitor SureCN1091571 family 2 2
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416148 CHEMBL2316872 Bioactive 3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
CFAMM00416147 CHEMBL2336040 Bioactive N-(3-methoxyphenyl)-4-methyl-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44512 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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