CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12515
Family Name Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]-1-cyanoethyl]-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxobutanamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00416297 Functional Category Bioactive
Superfamily Urotensin-2 and Cathepsin S Binder Superfamily
Class Class 4368

Cousin Family NamesSeedsMembers
Flovagatran family 12 546
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-lle-agly-ile-v... 17 7
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Cathepsin S inhibitor ethyl 2-[[3-[[(2S)-3-cyclohexyl-2-[(1-me... 3 8
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Cathepsin S inhibitor SureCN7397817 family 9 4
Cathepsin S inhibitor SureCN7062841 family 7 7
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 4 7
Cathepsin S inhibitor (2R)-N-[(3S)-1-benzyl-3-cyanopyrrolidin-... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 10 0
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
pyrrolidine-1,2-dicarboxylate NP ZINC04028685 Family 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416298 CHEMBL393166 Bioactive (2R)-N-[(1R)-1-cyano-2-phenylmethoxyethyl]-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxobutanamide
CFAMM00416297 CHEMBL231883 Bioactive (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]-1-cyanoethyl]-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxobutanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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