CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12517
Family Name Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[2-(3,5-dimethylphenyl)-5-[2-[2-fluoro-6-(trifluoromethyl)phenyl]acetyl]-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-3-yl]propyl]amino]ethyl]-1-methylpyridin-2-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00299657 Functional Category Bioactive
Superfamily Vasopressin V2 receptor Ligand YM-35278 Superfamily
Class Class 840

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor (3Z)-6-(2-methy... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[[(2S)-2-[... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416300 CHEMBL392843 Bioactive 1-[2-(3,5-dimethylphenyl)-3-[(2S)-1-[2-(oxan-4-yl)ethylamino]propan-2-yl]-1,4,6,7-tetrahydropyrrolo[3,2-c]pyridin-5-yl]-2-[2-(trifluoromethyl)phenyl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24503 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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