CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12537
Family Name Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-(cyclohexylmethoxy)benzonitrile family
No. of Seeds 8 No. of Other Members 30
Family Centroid CFAMM00416712 Functional Category Bioactive with Natural Product
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
SB1518 family 7 103
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Transient receptor potential cation channel subfamily V member... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Transient receptor potential cation channel subfamily V member... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Heat shock protein HSP 90-alpha inhibitor 4-[2-Chloro-6-(4,4,4... 2 6


External ID

Functional Category

Molecule Name

CFAMM00416712 CHEMBL2322146 Bioactive 5-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-(cyclohexylmethoxy)benzonitrile
CFAMM00416694 CHEMBL2322151 Bioactive 4-[[4-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-cyanophenoxy]methyl]cyclohexane-1-carboxylic acid
CFAMM00416717 CHEMBL2322149 Bioactive 4-[[4-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-cyanophenoxy]methyl]benzoic acid
CFAMM00416715 CHEMBL2322167 Bioactive 5-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-(2,2-dimethylpropoxy)benzonitrile
CFAMM00416697 CHEMBL2322165 Bioactive 5-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-(2-ethylbutoxy)benzonitrile
CFAMM00416696 CHEMBL2322170 Bioactive 5-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-[[2-(trifluoromethyl)phenyl]methoxy]benzonitrile
CFAMM00416713 CHEMBL2322147 Bioactive 3-[4-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-cyanophenoxy]-2,2-dimethylpropanoic acid
CFAMM00416695 CHEMBL2322150 Bioactive methyl 4-[[4-(2-amino-4-oxo-1H-pyrimidin-6-yl)-2-cyanophenoxy]methyl]benzoate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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