CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1255
Family Name Pol polyprotein inhibitor AC1LARNY family
No. of Seeds 28 No. of Other Members 17
Family Centroid CFAMM00321117 Functional Category Bioactive
Superfamily Beta-3 adrenergic receptor and Pol polyprotein Binder Superfamily
Class Class 630

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Pol polyprotein inhibitor (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5... 12 0
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrro... 19 1
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Histamine H3 receptor ligand SureCN2784306 family 5 3
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Pol polyprotein inhibitor (2S)-4-[2-[5-(4-fluorophenyl)-1,3-ox... 12 0
Pol polyprotein inhibitor pyridylthiophene analog 10 family 3 0
Pol polyprotein inhibitor ethyl)-amide family 4 0
Pol polyprotein inhibitor pyridylthiophene analog 16 family 4 0
Pol polyprotein inhibitor pyridylfuran analog 14 family 6 0
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3-ethyl-2... 5 3
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Pol polyprotein and Cytochrome P450 3A4 inhibitor (2S)-4-(3a,6... 2 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321111 CHEMBL85930 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-4-yl-1,3-oxazol-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321091 CHEMBL444533 Bioactive furanyl analog 2
CFAMM00321104 CHEMBL432550 Bioactive AC1LARNJ
CFAMM00321117 CHEMBL79236 Bioactive AC1LARNY
CFAMM00321084 CHEMBL85903 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-2-yl-1,3-oxazol-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321123 CHEMBL445944 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-3-ylfuran-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321090 CHEMBL314062 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[2-(5-pyridin-2-yl-1,3-oxazol-2-yl)propan-2-yl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321103 CHEMBL82245 Bioactive AC1LARNM
CFAMM00321083 CHEMBL81811 Bioactive AC1LARNG
CFAMM00321122 CHEMBL325829 Bioactive P3 benzofuran analog 8
CFAMM00321089 CHEMBL407828 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[2-(5-pyridin-4-ylfuran-2-yl)propan-2-yl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321102 CHEMBL313133 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-3-yl-1,3-oxazol-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321095 CHEMBL313623 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[2-(5-pyridin-3-yl-1,3-oxazol-2-yl)propan-2-yl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321121 CHEMBL312238 Bioactive AC1LARN4
CFAMM00321088 CHEMBL114756 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S,4S)-3-hydroxy-3,4-dihydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-4-ylfuran-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321101 CHEMBL313132 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[2-[5-(5-methoxypyridin-3-yl)-1,3-oxazol-2-yl]propan-2-yl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321127 CHEMBL445897 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[2-[5-(4-chloropyridin-3-yl)-1,3-oxazol-2-yl]propan-2-yl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321107 CHEMBL262643 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-(2-furo[3,2-c]pyridin-2-ylpropan-2-yl)-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321087 CHEMBL326796 Bioactive P3 furan analog 4
CFAMM00321100 CHEMBL324461 Bioactive P3 benzofuran analog 7
CFAMM00321126 CHEMBL313383 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-4-ylfuran-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide
CFAMM00321113 CHEMBL421330 Bioactive AC1LARNS
CFAMM00321093 CHEMBL311514 Bioactive AC1LARNA
CFAMM00321106 CHEMBL310417 Bioactive AC1LARND
CFAMM00321086 CHEMBL311953 Bioactive AC1LARO1
CFAMM00321112 CHEMBL310459 Bioactive AC1LARN7
CFAMM00321125 CHEMBL81974 Bioactive AC1LARO4
CFAMM00321118 CHEMBL315682 Bioactive (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(3S)-3-hydroxy-3,4,4a,8a-tetrahydro-2H-chromen-4-yl]amino]-5-oxopentyl]-4-[(5-pyridin-2-ylfuran-2-yl)methyl]-N-(2,2,2-trifluoroethyl)piperazine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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