CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12565
Family Name Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-methoxyphenyl)acetamide family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00416883 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 13
Class Class 855

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Ibrutinib family 2 27
MK-6096 family 3 69
PF-02545920 family 16 140
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 4 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 4 3
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Hepatocyte growth factor receptor ligand 5-[[6-(3-hydroxypheny... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Motilin receptor ligand SureCN2765637 family 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(4-methoxyphenyl)... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-(3,4... 1 8
Coagulation factor X inhibitor 2-(4-methoxyphenyl)-N-[5-(2-sul... 1 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 4
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 1 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 1
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
Adenosine receptor A2b and Adenosine receptor A1 ligand N-[(3Z... 2 2
Adenosine receptor A2b and Adenosine receptor A1 ligand 8-[1-[... 1 1
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00416884 CHEMBL2322924 Bioactive 4-methoxy-N-(5-methyl-2-phenylpyrazolo[4,3-d]pyrimidin-7-yl)benzamide
CFAMM00416883 CHEMBL402071 Bioactive N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-methoxyphenyl)acetamide
CFAMM00416882 CHEMBL270655 Bioactive N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]-2-(4-ethoxy-3-methoxyphenyl)acetamide
CFAMM00416881 CHEMBL2322931 Bioactive N-(2,5-diphenylpyrazolo[4,3-d]pyrimidin-7-yl)-4-methoxybenzamide
CFAMM00416879 CHEMBL403525 Bioactive 2-(3,5-dimethoxyphenyl)-N-[6-(3,5-dimethylpyrazol-1-yl)-2-pyridin-2-ylpyrimidin-4-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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