CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1257
Family Name 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1B ligand N-(4-chlorophenyl)-4-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-3,6-dihydro-2H-pyridine-1-carboxamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00321134 Functional Category Bioactive
Superfamily D(2) dopamine receptor Ligand Sertindole Superfamily
Class Class 471

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
D(2) dopamine receptor Ligand Sertindole Family 3 173
Transient receptor potential cation channel subfamily V member... 15 158
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Amg 423 family 7 47
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Coagulation factor X inhibitor 3-chloroindole compound, 20 family 4 5
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Transient receptor potential cation channel subfamily V member... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Receptor-interacting serine/threonine-protein kinase 1 ligand ... 1 11


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00321134 CHEMBL114780 Bioactive N-(4-chlorophenyl)-4-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-3,6-dihydro-2H-pyridine-1-carboxamide
CFAMM00321133 CHEMBL115663 Bioactive N-(4-chlorophenyl)-4-[3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indol-5-yl]-3,6-dihydro-2H-pyridine-1-carbothioamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543