CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1258
Family Name Purine nucleoside phosphorylase inhibitor 7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one family
No. of Seeds 10 No. of Other Members 34
Family Centroid CFAMM00321170 Functional Category Bioactive
Superfamily Purine nucleoside phosphorylase Binder Superfamily
Class Class 1306

Cousin Family NamesSeedsMembers
Tyrosine kinase Inhibitor PKI166 Family 17 198
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
Purine nucleoside phosphorylase inhibitor 2-amino-7-[[(2S,4R)-... 5 0
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Purine nucleoside phosphorylase inhibitor 2-amino-6-benzyl-1,7... 3 2
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Purine nucleoside phosphorylase inhibitor 3-[(2S,3S,4R,5R)-3,4... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11
Purine nucleoside phosphorylase inhibitor (3s)-3-(2-amino-4-hy... 2 0
Purine nucleoside phosphorylase inhibitor SureCN6353628 family 2 0


External ID

Functional Category

Molecule Name

CFAMM00321167 CHEMBL114781 Bioactive 2-amino-7-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
CFAMM00321154 CHEMBL541578 Bioactive 7-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride
CFAMM00321173 CHEMBL544117 Bioactive (2R,3S,5S)-2-(hydroxymethyl)-5-(4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)pyrrolidine-3,4-diol;dihydrochloride
CFAMM00321153 CHEMBL115146 Bioactive 7-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
CFAMM00321172 CHEMBL325862 Bioactive 7-[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxypyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
CFAMM00321171 CHEMBL538773 Bioactive 7-[(2S,5S)-3-hydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride
CFAMM00321170 CHEMBL288187 Bioactive 7-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
CFAMM00321143 CHEMBL117383 Bioactive 7-[(2S,4S,5S)-5-(fluoromethyl)-3,4-dihydroxypyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
CFAMM00321136 CHEMBL542455 Bioactive 7-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-6-fluoro-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride
CFAMM00321142 CHEMBL543164 Bioactive 7-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-5-methyl-1H-pyrrolo[3,2-d]pyrimidin-4-one;hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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