CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM126
Family Name Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658867 family
No. of Seeds 8 No. of Other Members 54
Family Centroid CFAMM00140006 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Family 2 2
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 11
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor 2-({3-[(3,5-Dichlorobenzyl)a... 5 7
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 8 3
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
Adenosine receptor A2a ligand (6E)-6-[4-amino-6-[(E)-2-(3-meth... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Tyrosine-protein kinase TXK and Tyrosine-protein kinase Lyn in... 1 1
Transient receptor potential cation channel subfamily V member... 1 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Thymidylate synthase inhibitor 3-(methylamino)-5,6-dihydro-4H-... 2 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Adenosine receptor A2a and Adenosine receptor A1 ligand N-benz... 3 12
Transient receptor potential cation channel subfamily V member... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00307659 CHEMBL316630 Bioactive 7-methyl-2-(4-nitrophenyl)-1H-1,8-naphthyridin-4-one
CFAMM00307610 CHEMBL102178 Bioactive 2-phenyl-7-piperidin-1-yl-1H-1,8-naphthyridin-4-one
CFAMM00307658 CHEMBL97757 Bioactive 7-fluoro-2-phenyl-1H-1,8-naphthyridin-4-one
CFAMM00307626 CHEMBL313864 Bioactive NSC679026
CFAMM00307655 CHEMBL102430 Bioactive 7-amino-2-phenyl-1H-1,8-naphthyridin-4-one
CFAMM00307675 CHEMBL104998 Bioactive N-[4-(7-methyl-4-oxo-1H-1,8-naphthyridin-2-yl)phenyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22954 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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