CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12638
Family Name Serine/threonine-protein kinase ATR and Serine/threonine-protein kinase mTOR inhibitor 4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine family
No. of Seeds 8 No. of Other Members 10
Family Centroid CFAMM00163356 Functional Category Bioactive
Superfamily Aurora kinase A and Luciferin 4-monooxygenase Binder Superfamily
Class Class 1154

Cousin Family NamesSeedsMembers
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Adenosine kinase inhibitor abt-702 family 14 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Transient receptor potential cation channel subfamily V member... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Transient receptor potential cation channel subfamily V member... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417460 CHEMBL2325705 Bioactive 4-[2-(1H-indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)pyrimidin-4-yl]morpholine
CFAMM00417453 CHEMBL2325711 Bioactive 4-[6-[1-(benzenesulfonyl)cyclopropyl]-2-(1H-indol-4-yl)pyrimidin-4-yl]morpholine
CFAMM00417458 CHEMBL2325699 Bioactive 3-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-8-oxa-3-azabicyclo[3.2.1]octane
CFAMM00417456 CHEMBL2325720 Bioactive 4-[2-(6-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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