CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12642
Family Name 5-hydroxytryptamine receptor 2B ligand SureCN1299437 family
No. of Seeds 6 No. of Other Members 7
Family Centroid CFAMM00417477 Functional Category Bioactive
Superfamily Mu-type opioid receptor and Survival motor neuron protein Binder Superfamily
Class Class 2757

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Prothrombin Inhibitor Dabigatran Family 7 182
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
JAK Inhibitor Momelotinib Family 33 83
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Class II cytokine receptor Ligand IL-10 Family 7 45
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 2 8
Aromatase Inhibitor 4-imidazol-1-ylmethylthioxanthen-9-one Family 2 4
Aromatase Inhibitor 2-(1h-imidazol-1-yl)-1-(4-nitrophenyl)etha... 2 29
Thromboxane-A synthase Inhibitor 2-(6-imidazol-1-yl-hexyl)-iso... 3 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 6
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prelamin-A/C inhibitor CHEMBL1611943 family 1 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Histamine H3 receptor ligand SureCN2878688 family 8 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 3 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 10 4
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 6
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 0
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Substance-K receptor ligand AGN-PC-074GCM family 2 2
Glucocorticoid receptor ligand SureCN13513652 family 1 0
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 1 0
Cellular tumor antigen p53 and E3 ubiquitin-protein ligase Mdm... 3 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-fluorop... 1 0
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417471 CHEMBL473185 Bioactive SureCN1298970
CFAMM00417477 CHEMBL474404 Bioactive SureCN1299437
CFAMM00417470 CHEMBL475245 Bioactive SureCN1298902
CFAMM00417476 CHEMBL474408 Bioactive SureCN1299050

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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