CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12643
Family Name Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 inhibitor N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide family
No. of Seeds 11 No. of Other Members 10
Family Centroid CFAMM00417496 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 Binder Superfamily 3
Class Class 1296

Cousin Family NamesSeedsMembers
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Rho-associated protein kinase 2 and Rho-associated protein kin... 4 9
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6


External ID

Functional Category

Molecule Name

CFAMM00417493 CHEMBL2325897 Bioactive N-[(1R)-2-[(3R)-3-cyanopyrrolidin-1-yl]-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417499 CHEMBL2325912 Bioactive N-[(2R)-1-(3-cyanopyrrolidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417492 CHEMBL2325902 Bioactive N-[(2S)-butan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417498 CHEMBL2325898 Bioactive N-[(1R)-2-[(3S)-3-cyanopyrrolidin-1-yl]-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417491 CHEMBL2325903 Bioactive 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417497 CHEMBL2325899 Bioactive 2-cyclopropyl-N-[(2S)-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417490 CHEMBL2325900 Bioactive 2-cyclopropyl-N-(1-cyclopropylethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417496 CHEMBL2325894 Bioactive N-[(2R)-1-(3-cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417495 CHEMBL2325895 Bioactive N-[(2R)-1-(3-cyanoazetidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417488 CHEMBL2325906 Bioactive N-[(2S)-3-cyano-3-methylbutan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CFAMM00417494 CHEMBL2325896 Bioactive N-[(1R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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