CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12650
Family Name Protein kinase C theta type and Protein kinase C delta type inhibitor (6E)-6-(1,2-dihydropyrazolo[3,4-b]pyridin-3-ylidene)-5-fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]pyridin-3-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00417514 Functional Category Bioactive
Superfamily 14-alpha sterol demethylase Inhibitor Voriconazole Superfamily
Class Class 627

Cousin Family NamesSeedsMembers
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 1 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417514 CHEMBL2325998 Bioactive (6E)-6-(1,2-dihydropyrazolo[3,4-b]pyridin-3-ylidene)-5-fluoro-2-[(3S)-3-[(2R)-2-hydroxy-3-methylbutan-2-yl]piperazin-1-yl]pyridin-3-one
CFAMM00417513 CHEMBL2326000 Bioactive (2R)-2-[(2S)-4-[5-fluoro-3-(hydroxymethyl)-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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