CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM12671
Family Name Trifunctional purine biosynthetic protein adenosine-3 inhibitor 2-[[4-[3-(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)-2-methylpropyl]benzoyl]amino]pentanedioic acid family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00417628 Functional Category Bioactive
Superfamily Trifunctional purine biosynthetic protein adenosine-3 and Dihydrofolate reductase Binder Superfamily
Class Class 3385

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pe... 4 23
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Dihydrofolate reductase and Trifunctional purine biosynthetic ... 1 6
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Folate receptor alpha and Trifunctional purine biosynthetic pr... 9 1
Thymidylate synthase inhibitor SureCN6446340 family 2 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)pipe... 17 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00417629 CHEMBL23388 Bioactive Tetrahydrohomofolate
CFAMM00417628 CHEMBL23699 Bioactive 2-[[4-[3-(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)-2-methylpropyl]benzoyl]amino]pentanedioic acid
CFAMM00417627 CHEMBL23278 Bioactive 2-[[4-[3-(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)-2-methylpropyl]benzoyl]amino]pentanedioic acid
CFAMM00417631 CHEMBL279302 Bioactive 2-[[4-[3-(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)propyl]benzoyl]amino]pentanedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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